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By binding to completely or partially complementary sites in the 3′-untranslated-region (3′UTR) of target mRNAs, miRNAs suppress the protein translation of these transcripts and/or degrade target mRNAs.
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Further evidence of multiple 5-HT3 receptor binding sites is suggested by the inability of excess ondansetron (as determined by competition binding) to completely block palonosetron-induced down-regulation.
Nevertheless, we cannot completely exclude the possibility that the HLA-E antibody had triggered antibody-mediated cellular cytotoxicity by binding to Fc receptors.
Antibodies attack antigens by binding to them.
Superior to competitive inhibitors, mechanism-based inhibitors exhibit higher potency by covalent binding to the target enzymes and completely and irreversibly inactivating them.
However, in the absence of SCR20, represented by the deletion construct CFHSCR15-19, binding to HcpA was completely abrogated (Fig. 4B).
In these RBC, CO binding to heme-iron completely prevented the dose- and time-dependent formation of MetHb induced by FP (not shown).
In order to assess the extent to which antisera elicited by MCPs bind to linear contiguous epitopes or conformationally dependent epitopes, antisera to 3 MCPs were examined for their binding to "native" and to completely denatured recombinant gp120.
Psychologists talk about the binding of one thing to another, taking a feeling that is absolutely unacceptable and suppressing it by binding it to another feeling which is completely acceptable.
mAb 215F12A4 (IgM) in vitro selectively recognized Tn on the MCF7 surface, since its binding to cell membrane was completely abolished by preincubation with purified Tn.
In contrast, two alanine mutations in hu3S193 Fc (e.g. I253A/H310A) were necessary to completely abrogate binding to muFcRn.
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CEO of Professional Science Editing for Scientists @ prosciediting.com