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It has been shown that S protein mediates viral infection by binding to cellular receptor ACE2 and thus induces membrane fusion.
PR8 NS1 is thought to antagonize IFNβ promoter activation (at least in part) by binding to cellular TRIM25, thereby preventing ubiquitination of the viral RNA sensor, RIG-I [3].
MSCRAMMs are a group of proteins that allow pathogens to either attach on host cells by binding to cellular ECMs or to be decorated by plasma Fn to evade the host immune response in the blood stream [1].
Hemagglutinin-neuraminidase glycoproteins (HN) in the envelope of several paramyxoviruses initiate the infection process by binding to cellular receptors.
EWS/FLI1 functions by binding to cellular partners in transcription and splicing, similar to the cellular machinery corruption by virus for virion production [ 55].
Although p53 inactivation pathways are not detected in every tumour, our study supports the hypothesis that p53 inactivation, either by binding to cellular or viral proteins or by mutation, is essential in the development of cervical carcinomas.
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The E1A proteins act by directly binding to cellular regulators that play key roles in controlling gene expression and cell growth.
However, doxorubicin distribution may not provide a 'global' or typical template for drug distribution due to the sequestration within the outer cell population caused by its avid binding to cellular macromolecules (Sutherland et al, 1979; Kwok and Twentyman, 1985; Tunggal et al, 1999).
CM-DiI was chosen because it is non-diffusible by virtue of its covalent binding to cellular thiols, and has been shown to be suitable for labeling and in vivo tracking of cells for at least 10 weeks [29], [30].
These EF data strongly suggest that 5-OH-PCB95 was enantioselectively biotransformed, either by enzymatic reaction (e.g., formation of PCB95 sulfate compound/s) or by enzyme-complex formation and binding to cellular tissues (e.g., complexation with reduced glutathione, GSH), or both in the whole poplar plants.
However, there was no data to demonstrate whether LANA can also regulate cellular gene expression by binding to the cellular chromosome DNA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com