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The teams show that Dbp5 is activated by binding to another protein, Gle1, and a small cofactor known as InsP6.
First, allosteric modulators can affect one receptor by binding to another receptor within a dimeric or oligomeric complex.
MIF binds to cell-surface CD74 [15] and the MIF-CD74 complex then activates signal transduction by binding to another cell-surface receptor, CD44 [14].
Data in Figures 1A C suggest that Aβ directly binds to CD36 based on its inhibiting cellular uptake of the CD36 ligand myristic acid, but we cannot exclude that Aβ inhibits myristate update indirectly by binding to another CD36-associated protein.
Conceivably, in AD the BDNF pro-domain is being stabilized by binding to another protein (44); this intriguing possibility requires further investigation.
Aurora A kinase can be switched on in two ways: by having a phosphate group added to its 'activation loop'; or by binding to another protein called TPX2.
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Another protein called Norrin can also activate Wnt signalling by binding to Frizzled and another receptor protein called Lrp5/6.
Aggrecan is retained in cartilage by binding to long filaments of another glycosaminoglycan, hyaluronan (HA), which is synthesized at the plasma membrane level by an enzyme called hyaluronan synthase (HAS) [ 36].
It has been hypothesized that p30 may function by binding to both RNA and to Rex, another HTLV-I protein that is conversely responsible for up-regulating tax/rex mRNA export from the nucleus [ 20].
It is possible, however, that LHR and HP1 co-associate by each binding to another protein rather than directly binding to each other.
APC activity is facilitated several fold by reversible binding to another hepatically synthesized, vitamin K-dependent protein known as protein S.
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