The polypyrimidine tract binding proteins (PTBPs), a family of multiple RRM domain containing proteins, regulate alternative splicing by binding to the polypyrimidine regulatory tracts that exist in introns [ 78, 79].
The metabolite effectors are generally able to mediate changes between alternative secondary structures by binding to a metabolite sensing domain of the RNA which prevents translation.
SRSF1 regulates this alternative splicing event by binding to a splicing enhancer in intron 6 and subsequent exclusion of an exon 3,4,5,6-cassette 3,4,5,6-cassettease 9b [ 108].
HBII-52 regulates alternative splicing of 5-HT2C bindinging to a silencing element in exon Vb.
For example, the snoRNA HBII-52 was found to regulate the alternative splicing of 5-HT2CR bindinging to a silencing element in one exon [16].
As an activator, Spo0A acts in conjunction with RNA polymerase containing either the housekeeping sigma factors sigma A or the alternative sigma factor, sigmaH, by binding to cognate sequences in the promoter regions of genes under its control [ 23].
2) The alternative and more common mechanism is by binding to partially complementary sequence in 3'UTR of target mRNA, leading to repression of protein translation [ 3, 8].
An alternative hypothesis is that rFVIIa acts by binding to activated platelets and activating factor Xa on the platelet surface, independent of the usual TF cofactor [ 22].
Cell cycle is driven by the alternative expression or degradation of different cyclins which exert their function by binding to different CDKs [ 19, 40].
An alternative agent for treatment of these diseases is pentamidine isethionate, which probably affects the parasite by binding to DNA.
