Sentence examples for by binding to active from inspiring English sources
PAK1 is activated primarily by binding to active Cdc42 or Rac1 [65], which in turn binds and activates MEK to stimulate ERK1/2 activation [66].
ROK-α is a direct effector of the Rho GTPase, which is activated by binding to active Rho [ 63].
While plant NOX proteins are directly regulated by calcium, phosphorylation [ 290, 297, 298] and by binding to active Rop GTPases, positive regulatory feedback between NOX-ROS and ROS-activated calcium channels is proposed to operate at the growing tip contributing to the tip-high cytoplasmic free calcium gradient both in pollen tubes and root hairs [ 290, 298].
PIAS3 acts by binding to active nuclear STAT3 (r18, event 57).
Inhibitor of apoptosis proteins (IAPs) are a family of proteins that block apoptosis in normal cells, by binding to active caspases, the proteases that mediate cell death.
The authors also concluded that the affinity for the L858R mutant to gefitinib was 20-fold higher than that for wild type, which could be explained by its tighter binding to active conformation of the tyrosine kinase domain.
Lysine interferes with the activation of plasminogen into plasmin by tissue plasminogen activator by binding to plasminogen active sites, thereby affecting the plasmin-induced MMP activation cascade [ 5].
By using spectroscopic measurement, they revealed that the inhibition of lipoxygenase 1 activity by curcumin can be due to binding to active center iron and curcumin after binding to the phosphatidylcholine micelles acts as an inhibitor of lipoxygenase 1.
Both of these compounds selectively inhibit PHD2 by binding to the active site within PHD2 where HIFs bind and stimulate HIF activity [ 2].
BSO depletes GSH by binding to the active site of GCLC non-covalently, inhibiting the activity of GCLC [23].
Some inhibitors work by binding to the active site of the enzyme domain within the AKT protein: this prevents ATP binding to the active site and thus inhibits the kinase activity of AKT.
