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Rab11a was reported to influence cell junction in vitro (Wang et al, 2000; Desclozeaux et al, 2008), therefore, we initially suspected that the epithelial leakiness in these mutant mouse intestines might be an enteritis-triggering factor (Su et al, 2009); however, this hypothesis was ruled out by barrier function tests.
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Furthermore, we tested the barrier function by treating HMVEC-L with LPS for 6 hours and afterwards added an EP4 receptor-agonist, ONO AE1 329 (30 nM).
In the presence of an intact epithelium, mucosal permeability is primarily determined by tight junction barrier function.
Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function.
Moreover, ROS cause proteinuria by modulating the barrier function of the glomeruli endothelial glycocalyx [ 52].
Emollients work in the treatment of AD by improving the barrier function of the skin.
The authors conclude that skin adaption as a barrier function was not harmed by tested skincare regimens in full term healthy infants.
The effect of histamine on the barrier function of the epidermis was tested by investigating the transdermal diffusion of tracer molecules.
The water repulsion assay also tests fur barrier function (Westerberg et al., 2004).
Assessment of oral antithrombotic therapy by platelet function testing.
We confirmed that a large percentage (25.6%) of the enrolled ASDs have an impaired intestinal barrier function, as assessed by the LA/MA test; GF/CF diet regimen tends to normalize the barrier impairment.
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