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There is a rapidly growing body of data describing DNA-protein interactions on a genome-wide scale, aided by availability of complete mammalian genome sequences and also the coupling of chromatin immunoprecipitation (ChIP) experiments [ 1- 3] with DNA microarrays analysis (ChIP-chip) [ 4- 10] or ultra high-throughput sequencing (ChIP-Seq) [ 11- 16].
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However, such an investigation is currently limited by the availability of complete interaction data.
The characterization of new virulence factors should now be greatly facilitated by the availability of complete genome sequences of two Xcc strains (strain ATCC33913 [14] and strain 8004 [15]).
Although it is currently limited by the availability of complete genome sequence and functional genomics data, the rapid pace of technological advancements in these areas will soon overcome those limitations, and we expect this methodology to gain widespread applicability.
Years of genetic research, recently aided by the availability of complete genome sequence of S. coelicolor [ 11], has identified several key players involved in the regulation of secondary metabolism in S. coelicolor.
The search for meningococcal antigens capable of inducing cross-reactive immunity has been revolutionized by the availability of complete genome sequences, and the resulting predicted proteins, from meningococcal strains of serogroups A, B and C [ 13- 15].
The limitations imposed on the secondary analyses by small sample size were magnified by the lack of availability of complete clinical data for many subjects due to lack of chart availability, such that Axis I diagnosis unknown for 15 subjects and suicide attempt history was only known for 39 subjects.
This is hampered by the lack of real-time availability of complete microbiological culture results and radiographic reports.
The study's findings are limited by the small number of subjects (particularly GPs), and the availability of complete sets of data for some of the analyses.
Most, if not all IDS assume the availability of complete and clean audit data.
Availability of complete genome sequences is listed as of 12/31/2007.
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CEO of Professional Science Editing for Scientists @ prosciediting.com