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The second group of genes was characterized by atypical expression patterns.
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Interestingly, this was also reported in the work of Bensellam and co-workers in which more than 400 mRNA probe-sets displayed atypical expression patterns, e.g. V- or inverse-V shaped across four glucose concentrations.
Despite their atypical expression pattern, the identification of platelet-associated and proliferative CTC subsets as being tumor-derived is established by their inclusion of lineage-tagged tumor cells.
However, neither the mechanism nor the functional consequence of this atypical expression pattern is entirely clear for most, if not all, CTAs.
Unique or atypical mRNA expression patterns of maternal proteins suggest their key roles in oogenesis or early embryo development and this notion has been validated by other functional research on maternal effect proteins [ 7- 11].
Duplication of SWEET11 was most likely followed by neofunctionalization as evidenced by divergent expression patterns.
Clusters were established by normalized gene expression patterns as shown in gene expression view.
Expression patterns were validated by confirming mRNA expression patterns with conventional molecular techniques.
Interestingly, explanted lung cells from young and old mice showed a similar expressional pattern, with atypical expression levels in cells originating from old mice lungs.
Acquisition of this phenotype was accompanied by large shifts in gene expression patterns (Fig. 1c).
These members are encoded by different genes and have different tissue expression patterns.
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