By associating gene expression patterns across 32 tissues to molecular attributes used in this study (old, new, disease, non-disease, etc).
Nodes have associated expression measurements.
Along these lines, complementary findings can be obtained by comparing gene expression patterns associated with adolescent exposure to methylphenidate and atomoxetine, another widely-used ADHD drug without stimulant-like effects and assumed to be devoid of abuse liability, in view results from a previous study which showed differential effects of these drugs in SHRs [ 60].
The different subgroups, identified by unique expression patterns, were associated with clinical parameters such as overall survival.
The co-expressed gene clusters identified by PAM are associated with distinct expression patterns as well as over-representation of different functional GO categories.
Hundreds of functional modules, as defined by Gene Ontology, were associated with conserved expression patterns but bear no overt relationship to ESC development, suggestive of new mechanisms critical to ESC pluripotency.
Out of 10 prognostic markers tested, two genes (SPARC and SPP1) were significantly associated when gene expression patterns were measured by qRT-PCR in the independent cohort.
Our findings support the hypothesis that neuroblastoma consists of two biologically distinct subgroups that differ by characteristic gene expression patterns, which are associated with divergent clinical outcome.
By contrast, most of the ESTs and introns we studied are well annotated, making it easy to acquire information associated with their expression patterns and levels.
By associating studies with shared patterns of differential gene set and gene expression, REx facilitates the analysis of the retrieval results.
