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Using a test lung and dogs, Brunner et al. modified this method by applying multiple correction factors, equations, and mathematical modeling to determine ƬE [ 16].
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Significant differential expression was calculated using the Beadstudio software by applying multiple testing corrections using Benjamini and Hochberg False Discovery Rate (FDR) [28], [29].
The false discovery rate (FDR) is controlled by applying multiple testing corrections to the cytosine level tests within each region.
By applying the multiple-correction method described in Section 2, it is not difficult to check that if (0le kle20), then lim_{nrightarrowinfty}n^{2k+4}E_{k}biggl( frac{1}{2};nbiggr)=C_{k}biggl(frac{1}{2}biggr), (4.4) here (C_{k}(frac{1}{2})) is a computable constant depending only on k.
We applied multiple testing corrections.
We applied multiple-hypothesis correction by following Benjamini-Hochberg algorithm to calculate false discovery rates (FDRs) based on P values from ANOVA [ 20].
Q-values are derived from P-values by applying a Multiple Testing Correction (MTC) procedure.
After using a Spearman correlation test followed by applying a multiple testing correction at a FDR of 5%, we found 1,847 genes to be positively correlated and 1,445 genes to be negatively correlated with TWIST1 mRNA expression (Additional file 3: Table S9A, B).
With the small size of the minimum d-separating sets, we can do the permutation comparisons by applying Bonferroni correction for multiple testing to renew the significant threshold for each of the n individual tests to maintain an experiment-wise error rate.
Statistical significance of Mantel test was corrected a posteriori for multiple testing by applying Bonferroni correction.
However this chosen α-level was adjusted for multiple comparisons by applying Bonferroni correction in GEE model.
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