We furthermore tried to assess the functionality of ExAC-listed leptin variants by applying a knowledge-driven approach.
In addition, we estimated the function of leptin variants by applying a knowledge-driven approach, based on findings described in mutagenesis studies.
Using exome sequencing data from ExAC, in silico prediction tools and by applying a knowledge-driven approach, we identified 27 probably damaging variants in the leptin gene of 58 heterozygous subjects.
This business university is redefining business education and application by applying a combination of knowledge, experience transfer and acquisition, along with new hires, partnerships and collaboration with entrepreneurs.
Other researchers have suggested changes to improve ontologies' structures and axioms based on applying formal, ontological and philosophical methods [ 21, 55, 66, 67, 71, 72], or they provide ontological interpretations of domain-specific knowledge by applying a formal ontological theory to some phenomena in a domain [ 67, 73 75].
Research suggests that learners can succeed in new situations by applying generalized abstract knowledge (Gick & Holyoak, 1983) or by applying a specific prior instance (Ross, 1984).
Furthermore, having a dedicated team enabled delivering a demonstrator after only two years by applying an Open Innovation approach, pulling knowledge from external experts in automation and iteratively integrating this with own organizational capabilities including technology platform, manufacturing strategy, design for manufacturing/assembly and integrated product and process development.
This approach (as well as the other examples included in Table 1) transforms a typical exercise into a complex problem, inviting students to generate possible scenarios by applying their knowledge of a generalized system (chromosomal inheritance) to a specific application.
Once the basic facts of a particular lesson have been taught, it is often necessary to reinforce the knowledge the students have just acquired by giving them some form of exercise in which they have to demonstrate their understanding of what they have learned by applying the knowledge to a specific situation.
By applying previous knowledge of how a rat whisks in different situations, they created a computational model that realistically simulates real rats' whiskery explorations (see video).
The aim of the paper is to present an integrated design of a coastal defence, by applying the knowledge gained within DELOS (EVK3-CT-2000-00041, www.unibo.itibo.ito to an existing prototype case.
