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The evidence for several rounds of recent and ancient polyploidization events found by analyzing the genomic sequence data suggests the importance of whole-genome duplication in the evolutionary success of angiosperms [ 4, 5].
We started this work by analyzing the genomic organization of α-tubulin genes in the Leishmania braziliensis genome database.
By analyzing the genomic coverage rate and sequence similarity of homologous regions for the four different genomes, we found that there is a higher degree of similarity between ATCC11845 and both RA-CH-2 and RA-GD than RA-CH-1.
We identified a list of lncRNAs closely linked to ABCB1 in the Turquoise module (Table 2), indicating that some of these lncRNAs may function as regulators of ABCB1 By analyzing the genomic location of the lncRNAs linked with ABCB1, we found that several lncRNAs were located at the regions overlapping or near the ABCB1 gene locus.
Most testing for JAK2 mutations is performed by analyzing the genomic DNA of the JAK2 gene.
Such modules could consequently be found by analyzing the genomic regions most affected by chromosomal instability.
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We determined by analyzing the mouse genomic contig (Mus musculus, Genbank Accession No. NT_039495) that Spatial is composed of 10 exons (Fig. 3A).
Short, incomplete or highly diverging amino acid sequence predictions were curated manually by analyzing the corresponding genomic sequence (including full intron sequences and flanking regions) with respect to consensus for splice donor and acceptor sites and sequence homology to other family members.
Detection of mutations was done by analyzing the alignments, and genomic positions which were consistently (>60%, coverage of 5 or more reads) different were marked as mutated.
By analyzing the extent of genomic alterations and their subclonal and clonal status within the tumor mass of sporadic hemangioblastomas, this issue can be addressed.
Support for orthology of these globin proteins was further obtained by analyzing the organization at the genomic level.
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