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Uptake of SPIO was seen in circulating blood monocytes (data not shown) and tissue macrophages by analysis of tissue specimens from spleen and liver of animals that were injected with Alexa Fluor® 488 hydroxylamine IgG-SPIO nanoformulations following the MRI tests (Figure 8).
By analysis of tissue sections of parietal peritoneum, peritoneal thickening occurred in the MGO-, FA-, CG-, and talc-treated rats.
Male-biased, age-associated increases in kidney fibrosis and mononuclear cell infiltration were observed by analysis of tissue sections (Table 1; Additional file 1).
Assays of serotonin and its metabolites can be performed by analysis of tissue homogenates, by microdialysis or by analysis of body fluids (blood, urine or CSF) [ 28– 30].
Hypoxic regions in tumours of experimental animal models can be assessed post-mortem by analysis of tissue sections, following i.v. administration of pimonidazole, a 2-nitroimidazole compound, which is selectively reduced and binds to intracellular macromolecules in hypoxic regions at pO2 < 10 mm Hg (Dearling et al, 2004).
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Regional myocardial displacement was obtained by analysis of color tissue Doppler apical images acquired at peak stress.
The relevance of WT1 expression in prostate cancer was confirmed by analysis of tumor tissue and cell lines, suggesting a potential role for WT1 in prostate tumorigenesis.
This notion is supported by analysis of lung tissue from healthy accidental-death victims from Mexico City showing neutrophils attached to damaged capillary endothelial cells (Calderón-Garcidueñas et al. 2007).
Virtual microscopy combined with computer vision techniques can aid the human observer by analysis of large tissue areas at a high magnification.
The only variant Creutzfeldt-Jakob disease (vCJD) patient identified in the United States died in 2004, and the diagnosis was confirmed by analysis of autopsy tissue.
The efficacy and specificity of OPN, TSP-1 and TYRP-1 antibodies in IHC was tested by analysis of frozen tissue xenografts of known target gene expression [ 2, 5].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com