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Reversal drives could overwrite unwanted changes introduced by an initial drive or by conventional genome engineering, even restoring the original sequence.
Research should assess the extent to which the residual presence of guide RNAs and/or Cas9 after reversal might affect the phenotype or fitness of a population and the feasibility of reaching individual organisms altered by an initial drive.
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Then the Giants' offense smacked the Texans with an initial drive of 10 plays for 66 yards capped by Tiki Barber's easy 1-yard sprint around right end.
This reversal gene drive will restore the organism to the previous genetic state, and even to the original genetic sequence overwriting the introduced changes inserted by the initial drive (Oye et al., 2014).
Flame propagation is highlighted by an initial flame acceleration phase driven by turbulent burning in the cylinder wakes.
Following an initial recruitment drive by email, we recruited further participants using flyers at trainee teaching sessions and snowballing.
His concern was only that such theorising should be properly grounded, and that it should not be driven, for example, by an initial failure to keep track of distinctions that we mark in our ordinary use of language.
Jamie Reckord's cross from the left fell to the winger at the back post and, although his initial drive was pushed away by Dan Twardzik, Dingwall drilled low into the net.
Manning was 4 for 4 on his initial drive and Plummer responded with a 5-for-5 first drive that resulted in a 49-yard field goal by Jason Elam.
The developed consistent projection method are also applied for simulation of interface evolution of an initial ellipse driven by the surface tension and of an initial sphere bubble driven by the buoyancy with good accuracy and good resolution.
The main worry was that, in advanced economies, after an initial recovery driven by the inventory cycle and fiscal stimulus, growth would fizzle.
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