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By contrast, high-extraction substrates may be affected less by an increased level in UGT activity as their clearance is limited by hepatic blood flow.
Indeed, increased stress was indicated by an increased level of zeaxanthin relative to members of the xanthophyll cycle (Fig. 2 and Fig. S3 in the ESM) since the amount of zeaxanthin synthesized via the xanthophyll cycle is highly correlated with the level of energy-dependent quenching in most plants (Jahns and Holzwarth 2012; Müller et al. 2001).
In addition, we found that acquired resistance is accompanied by an increased level of cell surface EGFR and increased phosphorylation of HER-2 and HER-3.
Species of highly drained soils with poor competing capacity (like the specialist weed Arenaria serpyllifolia) could have been eliminated by an increased level of fertilization and the resulting increased competition with other plants, mostly the crop itself.
Taken together, these data indicate that acquired resistance to ICR62 was accompanied by an increased level of cell surface EGFR and increased phosphorylation of both HER-2 and HER-3.
In this study, we have found that acquired resistance to the anti-EGFR antibody ICR62 in colorectal cancer cells was accompanied by an increased level of cell surface EGFR and increased activation of pHER-2 and pHER-3, which was accompanied by increased phosphorylation of MAPK and Akt in DiFi62 cells.
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As expected, LY379268 activated both the MAP kinase and the PI-3-K pathways, as shown by an increased levels of phosphorylated ERK1/2 and phosphorylated Akt, respectively.
Over six months, that slightly shaky start was slowly replaced by an increasing level of confidence as Blair settled into his new role.
In the last 20 years QSAR analysis has been characterized by an increasing level of sophistication as technological and computational developments have made it possible to measure or compute a higher number of chemical and physical parameters [2].
By applying a set of appropriate thresholds on these two items, we can define three groups with genomic scores 1, 2 and 3, characterized by an increasing level of genomic perturbation.
Originally managed "by hand", software deployment demands an increasing level of automation and autonomy.
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