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6 According to an "outside-in" paradigm, MS is caused by an exogenous factor, such as an infection, which in genetically susceptible individuals induces the activation of naïve autoreactive T and B cells present in the immune repertoire.
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It has been suggested that an atypical pattern of vascular reactivity and response, or flare of facial vasodilation (flushing) induced by an exogenous trigger factors, are some of the most likely causes for such cases.
Accretion was triggered by the exogenous factor of fire exclusion, and inflection and recession apparently were driven by the endogenous factor of density-dependent mortality combined with exogenous factors such as climate.
The mechanism by which the exogenous factor acts is independent of neuronal nitric oxide synthase.
The pathogenic aggregation of α-syn can be modulated by endogenous and exogenous factor, such as metals and pesticides, genetic mutations in SNCA, post-translational modifications and protein-protein interactions [ 186].
The onset and clinical outcome of an attack is commonly influenced by several exogenous factors simultaneously, and endogenous factors, such as the residual activity of a mutated protein, individual differences in other metabolic pathways in the liver and in neuronal protection capacity, may modify the clinical outcome.
However, the phenotype of an individual is also regulated strongly by the exogenous factors, which may temporarily interfere with the homeostasis and the metabolic routes of endogenous steroids.
LuxR solos regulate target genes by either sensing endogenous QS factors or by 'eavesdropping' on exogenous factors produced by neighboring bacteria [ 62].
Lacking of cognate LuxI proteins, LuxR solos regulate target genes by either sensing endogenous QS factors or by 'eavesdropping' on exogenous factors produced by neighbouring bacteria.
In 2014, a study of more than a million online restaurant reviews, on sites including Foursquare, GrubHub, and TripAdvisor, found that the ratings were influenced by a number of "exogenous" factors, unrelated to food quality — among them menu prices (higher is better) and the weather on the day the reviews were written (worse is worse).
This implies that the two careers are jointly determined by a set of exogenous factors.
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