Sentence examples for by an additional mutation from inspiring English sources

This hypothesis would also suggest that the viability of a dam recB strain should be restored by an additional mutation (e.g., mutL or mutS) that inactivates mismatch repair.

However, later, all of the expression defects of the xpr mutant were found to be caused by an additional mutation in agrC, the gene encoding agr sensor kinase [29].

To exclude the possibility that our colony is affected by an additional mutation leading to the phenotype, we confirmed these results on animals bred in another colony (data not shown).

Metal affinity is further diminished by an additional mutation, to Glu286, which indirectly coordinates zinc by binding the nucleophilic water.

However, even in the absence of His166 (in the H166S background), redirection of SB deprotonation to the CP side can be restored by an additional mutation, R215W, in SRI (ref (7) and Figure 5, green line), a suppressor mutant known to revert the repellent phototaxis signaling phenotype of SRI HtrI mutant complexes into an attractant response.

The existence of such different mechanisms is further supported by the observation that the concentration of the transcriptionally active forms TAp63 αFTL/IKEE>AAA/ILEE and TAp63 αFTL>AAA that are barely detectable in western blots strongly increases when they are rendered transcriptionally inactive by an additional mutation in the DNA-binding domain.

We show that the molecular and cellular deficits of an AS mouse model can be rescued by introducing an additional mutation at the inhibitory phosphorylation site of alphaCaMKII.

However, the cells quickly overcame this growth defect by gaining an additional mutation.

To completely inactivate the enzyme so that it could form a stable complex with the diubiquitin substrate and the UIM-SH3 construct, we had to introduce an additional mutation by changing an active-site zinc-coordinating Asp to Ala.

An additional mutation (probably caused by a translocation) had to occur to explain the gap between 6.10 and 6.7.

Furthermore, this double-heterozygous phenotype can be enhanced by an additional heterozygous mutation in the Cap-D3 gene and suppressed by a heterozygous mutation in the Slimb E3-ubiquitin ligase (Hartl et al. 2008a; Buster et al. 2013).