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The polarity in this system is apparently determined by an activity gradient in such a way that a hydranth regenerates wherever the metabolic rate is highest.
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In holometabolous insects Toll signaling is activated by ventral eggshell cues and forms an activity gradient (red) that is essential at the very least for specifying the ventral-most cells on the DV axis, giving rise to the mesoderm (brown), by activating the gene twist (twi ) (black arrow).
In the developing limb bud, by inducing different levels of Vangl2 phosphorylation, Wnt5a gradient is translated into an activity gradient of Vangl2.
There was an activity gradient down the thigh muscle, the proximal tracer uptake being highest, and this gradient was steeper in patients than in controls; the activity decreased by 0.00024 and 0.00010 SUVmean mm−1, respectively, along the thighs.
This also indicates that the gradient is an activity gradient, not an expression gradient.
For women, we identified a physical activity gradient by education level.
We provided evidence that BMP exists in an apical-basal activity gradient and that BM regulates ISC self-renewal by confining high BMP signaling to ISCs.
10.7554/eLife.01857.023 Figure 8. Regulation of ISC self-renewal by Vkg and BMP activity gradient.
This unrestricted diffusion leads to an absence of activity gradient.
It was shown that the Bmp activity gradient is defined by a'shuttling-based' mechanism, whereby the Bmp ligands are translocated ventrally through their association with Bmp inhibitor Chordin.
Furthermore, the model concerning cofilin activity gradient generated solely by LIMK1 activity was not found particularly convincing.
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