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By altering transcript levels, and presumably the levels of encoded proteins, memory genes are likely to alter the cellular responses and the crosstalk between overlapping pathways.
This is the first demonstration that a MVT preparation significantly altered the myocardial [ 38, 39] gene expression pattern by altering transcript levels of several genes in both diabetic and healthy rats.
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As an obligate autotroph, H. akashiwo is dependent on chloroplast function for survival and responds to changing environmental cues by rapidly altering transcript levels within the plastid [ 18, 19].
DOX disrupted cardiac mitochondrial biogenesis, as demonstrated by decreased mtDNA levels and altered transcript levels for multiple mitochondrial genes encoded by both nuclear and mitochondrial genomes.
We selected several differentially expressed genes (Tgfb1, Tnf, Fosl1, Mmp2, Irf7, Hmgb2, and Hdac2) and could confirm altered transcript levels by quantitative real-time PCR using cDNA from back skin of wt and Rage -/- mice 24 hours after TPA treatment (see Additional file 4).
The regulation of gene expression is often analyzed at the level of transcription, although it is well established that altered transcript levels are not necessarily reflected by the corresponding protein levels [ 16].
The combined results of reversal of stunting in plants over expressing PKV by exogenous application of GA and the altered transcript levels of GA biosynthetic genes suggests that PKV regulates plant development by functioning in critical signaling pathways involved in GA metabolism and GA-regulated transcriptional networks.
Our data suggest the existence of two phases of the TPA response: an initial Rage-independent response that is followed by a second Rage-dependent maintenance of the altered transcript levels.
Under salt stress, OsAPX2, OsAPX7, and OsAPX8 show altered transcript levels [168], but only OsAPX8 is induced in roots [55].
Integration of hippocampal expression data from the same female mice found stress-related hydroxymethylation correlated to altered transcript levels.
Nineteen cell wall-related genes have altered transcript levels in 35S::PCN-miRNAd (Table 2).
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