A second perspective is that the HCRT system influences DA signaling by altering the state of DA terminals, likely via changes to DAT sensitivity.
In our next study, we will attempt to elucidate the influence of the chemical structure of the synthetic polymer on cell behavior by altering the composition of the main chain and/or the terminal functional group of the side chain.
Activation of ionotropic and metabotropic receptors on the terminal membrane can be expected to regulate spike generation by altering the voltage-dependence of calcium channel activation, the threshold for regenerative depolarization, and the properties of voltage noise [ 8, 43].
Here we demonstrate a mechanism by which the intracellular, carboxy-terminal tail of polycystin-1 (CP1) regulates mTOR signaling by altering the subcellular localization of the tuberous sclerosis complex 2 (tumor tumor suppressor, a gatekeeper for mTOR activity.
This dilemma was resolved in part with the structure of an extended, unliganded gp120 core, by altering the truncations to the V1/V2 and V3 loops and incorporating additional N-terminal residues.
Following an attempted ramraid attack at Glasgow Airport in 2007, several airports stepped up security at entrances by altering the pick-up and drop-off zones to prevent private cars getting too close to terminal buildings.
IDR-1002 altered the IL-1β-induced proteome primarily by altering the expression of members of nuclear factor kappa-B (NF-κB) and c-Jun N-terminal kinase (JNK) pathways.
It is possible that phosphorylation of these sites affects eEF2K activity by altering the conformation of the 'linker' region and thereby the efficiency of the 'coupling' between the C-terminal and kinase domains of eEF2K.
In conclusion we have demonstrated that the structural element responsible for GSTM2 cell translocation is the C-terminal globin-like domain and that gains in cell translocation efficiency may be achieved by altering the conformational stability of this domain.
By altering the phase and amplitude, each "neuron" is tunable.
