Sentence examples for by altering the splicing from inspiring English sources

SF3B1 mutations could drive dysplasia and malignancy by altering the splicing pattern of oncogenes or tumour suppressors (Gentien et al, 2014).

Here also single nucleotide polymorphisms played a critical role in 5' splice site and create a cryptic splice site by altering the splicing signal.

The rs2004640 T allele creates a 5' donor splice site in an alternate exon 1 of IRF5 and might thus have a functional role by altering the splicing of exon 1 of the IRF5 [ 2].

This phenomenon indicates that SNPs impede the disease genes (AD, ID) to take part in alternative splicing by altering the splicing signals and their lower involvement with alternative splicing than IG genes may imposes much more evolutionary pressure on disease genes.

Several studies have shown that some missense mutations, located in exonic splicing regulatory elements, can cause diseases by altering the splicing machinery process [ 15].

Our results demonstrate that one way DNA methylation could regulate these genes is by altering the splice variant landscape.

By altering the balance of splice isoforms encoded by human genes or by promoting the expression of aberrant oncogenic splice variants, cancer cells enhance their ability to adapt to the adverse growth conditions of the tumoral microenvironment.

Overall, our results strongly support a role for SMN protein in SMN exon 7 splicing by altering the abundance of a subset of snRNPs.

We propose that TGF-β1 mediates differential splicing of fibronectin by altering the relative expression and/or phosphorylation pattern of several of these splicing factors, which interact to promote alternative splicing.

Similarly, mutations in introns of p53 gene can alter p53 activity either by affecting alternative splicing or by altering the activity of the internal p53 promoter located in intron 4. As p53 isoform can modulate p53 transcriptional activity and p53-mediated apoptosis, the ratio between p53 isoforms can be an important cell fate determinant.

Since some lncRNAs exhibit splice variant-dependent activity, splicing aberrations first initiated by deregulated NC-RNA expression have the potential to propagate further pro-metastatic changes by altering the activity of other lncRNAs.