Sentence examples for by altering the local from inspiring English sources
Acetylation of histones and methylation of histones and DNA cytosine residues are part of the complex epigenetic regulatory process determining lineage-specific gene expression by altering the local structure of chromatin.
As PIP2 binds to an array of actin-binding proteins in cells [27], [28], [43], the fine structure of the actin cytoskeleton can be modified by altering the local levels of PIP2 [44].
Thus increasing or decreasing the rate of O2 consumption by mitochondria may be an important aspect for modifying O2− production in vivo by altering the local [O2] [ 19].
Voltage-tuned nanopores are modeled with Brownian dynamics and are predicted to filter nanoparticles by altering the local electric field within the pore.
On the other hand, such dams can have profound effects on the survival, density and distribution of disease vectors and parasites such as malaria, by altering the local ecology and habitats.
These three changes affect population diets, and raise concerns about undernutrition, obesity and non-communicable diseases, by altering the local availability, nutritional quality, price and desirability of foods [ 2, 4, 5].
It has been seen in gramicidin channels that altering the local curvature by asymmetric lipids can change the coupling to lateral tension.
We discuss the recent discovery that CpG methylation increases DNase I cleavage at adjacent positions by an order of magnitude through altering the local 3D DNA shape and the possible implications of this structural insight for understanding the methylation sensitivity of transcription factors (TFs).
The recent demonstration that VEGF signaling is modulated by the Notch signaling pathway, however, suggests that inhibiting Notch signaling may enhance regional neovascularization, by altering the responsiveness of local endothelial cells to angiogenic stimuli.
A perhaps less obvious mechanism by which p53 might promote or retard aging is by altering the systemic or local tissue milieu.
Loss of ionocytes, with consequent loss of ion-modulating pumps and channels, could affect the development of ciliated cells by altering the ionic properties of the local environment.
