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The trick is achieving "knock down" by altering the functioning of targeted proteins within a designated cell -- no trivial task.
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By altering the functions of the cricket's central nervous system, the worm coerces it into jumping slap bang into the nearest body of water.
This chapter reviews an experimental evidence suggesting that Doxorubicin (DOX) and other anthracyclines can act at an intracellular level, perhaps by altering the function of iron regulatory proteins (IRP) that serve to maintain low molecular weight iron pool (often referred to as the labile iron pool, LIP) within physiologic concentrations.
In Huntington's disease (HD), mutant huntingtin (mHtt) disrupts the normal transcriptional program of disease neurons by altering the function of several gene expression regulators such as Sp1.
It has been suggested that genetic variations in the genes encoding the inflammatory cytokines might confer susceptibility to DN by altering the function and/or expression of these cytokines.
Other HPV proteins act indirectly by altering the function of cellular factors.
Second, after initial TBI, the exaggerated inflammatory response may cause CIRCI by altering the function of the hypothalamic pituitary adrenal axis.
Inflammation can reduce the anti-atherogenic and anti-oxidant properties of HDL by altering the function of key enzymes important to the metabolism of HDL.
Hence, impairment of the testicular transcriptional network by altering the function of transcription factors through modulation of their mRNAs or their translation could play a putative role.
As members of the Gαq family are known to regulate mitogenic pathways [ 39], Fhit may exert its tumor suppressive effect by altering the functions of these Gα subunits.
Does intrauterine biosynthesis of estrogen play an important role in early pregnancy by altering the function of uterine natural killer (uNK) cells?
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