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Mutations, which are less common, often cause disease by altering the function of a key protein.
This chapter reviews an experimental evidence suggesting that Doxorubicin (DOX) and other anthracyclines can act at an intracellular level, perhaps by altering the function of iron regulatory proteins (IRP) that serve to maintain low molecular weight iron pool (often referred to as the labile iron pool, LIP) within physiologic concentrations.
In Huntington's disease (HD), mutant huntingtin (mHtt) disrupts the normal transcriptional program of disease neurons by altering the function of several gene expression regulators such as Sp1.
It has been suggested that genetic variations in the genes encoding the inflammatory cytokines might confer susceptibility to DN by altering the function and/or expression of these cytokines.
Other HPV proteins act indirectly by altering the function of cellular factors.
Hence, impairment of the testicular transcriptional network by altering the function of transcription factors through modulation of their mRNAs or their translation could play a putative role.
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Taken together, these findings confirm a role for oxidative regulation of inflammation by altering the functions of extracellular mediators such as alpha(2 M.
By altering the functions of the cricket's central nervous system, the worm coerces it into jumping slap bang into the nearest body of water.
The trick is achieving "knock down" by altering the functioning of targeted proteins within a designated cell -- no trivial task.
As members of the Gαq family are known to regulate mitogenic pathways [ 39], Fhit may exert its tumor suppressive effect by altering the functions of these Gα subunits.
We remedy it by altering the above function as f(n, x) = x*n.
More suggestions(18)
by modifying the function
by altering the position
by altering the functionality
by altering the functional
by altering the phase
by altering the configuration
by altering the elongation
by altering the mesoscopic
by disrupting the function
by altering the account
by defining the function
by altering the organism
by altering the presentation
by altering the microstructure
by altering the model
by altering the meaning
by altering the rate
by perturbing the function
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