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These are a few examples of how a clinically and commercially beneficial drug product could be launched in the market by altering the formulation strategies.
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These results demonstrated the possibilities of modulating the release profile by means of the processing parameters rather than through the classical approach of altering the formulation.
By altering the Hodgkin-Huxley formulation for neuronal cells to allow for trans-membrane potassium (K+) flow through two types of channels (one in which conductance falls with membrane depolarization and another in which it slowly rises), Denis Noble was able in 1960 to reproduce the AP morphology of Purkinje cells.
We hypothesize that by altering the dosing regimen or formulation of CQ, it might be possible to reinstate CQ into antimalarial chemotherapy by making use of this novel mechanism.
In conclusion, our capsule is easily modified to accommodate different release rates for protein-type drugs by altering the membrane COL composition and/or drug formulation and can be implanted and removed with minor surgery.
By altering the phase and amplitude, each "neuron" is tunable.
The honeycomb architecture was modified by control of the honeycomb cell size, and hence surface area to enable control of drug release profiles without the need to alter the formulation.
Since this volume was found to be too small for accurate measurement and administration to the mice a diluted version was prepared by simply dissolving only 0.26 mg Dox per mL of formulation without altering the composition of the gel.
It may be worthwhile studying whether this 'warm up' period can be shortened by altering iontophoresis parameters like current, buffer formulation, temperature and analyte of interest.
This work provides an updated review of (a) the physiopathologic changes altering the skin of DM patients, and (b) the dermocosmetic formulations adapted to these conditions.
They decided that altering the product would be easier than altering users' behavior, and the company replaced the previous formulations with Purell Advanced, which feels and smells the same as the old version but is effective when applied in smaller quantities.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com