Taken together, these results suggest that the combined actions of cytochalasin D on binding to F-actin barbed ends and modulating F-actin dynamics by altering the nucleation pool available for microfilament elongation is the most likely reason for its striking effect on the ECM patterning of TSPs.
Recently, AtCPK28 was reported to regulate plant stem elongation and vascular development by altering the expression of NAC transcriptional and gibberellic acid homeostasis regulators [ 52].
Hence, it is likely that curcumin is capable of enhancing the neurite elongation of either precursor or differentiated neurons by altering the histone acetylation pattern of differentiation-related genes [ 27, 50, 51].
Tensile testing of SPU films at 37 °C in phosphate buffered saline (PBS) indicated that the Young's modulus and elongation of the polyurethane copolymers could be tailored by altering the soft segment block length.
Unexpectedly, the E3 ligase that targets H2B for ubiquitination, RNF20, acts as a repressor of transcription, ostensibly by altering the dynamic phosphorylation of the CTD of Pol II that determines its initiation, elongation and termination.
By altering the concentration of hygromycin B and the time when it was added, we were able to empirically capture the positions of ribosomes after they had loaded and started elongation.
Elongation was readily determined to be proportional to the monomer concentration (Fig. S3), as previously observed by solution-state measurements (6), implying that the presence of the surface does not significantly alter the elongation mechanism.
This may alter the elongation rate of RNAPII transcribing Helitron-captured genes.
Let us assume as a null hypothesis that the function of the new gene is not altered by the elongation of the first sequence.
As DNA methylation regulates transcript levels by altering chromatin structure and regulating the elongation by RNA polymerase II (RNApII) and through the human transcription elongation regulator interacting with RNApII at the Serine 2 position (RNApIISer2), we determined whether treatment with 5-azaC and VitC modulates DNA methylation at exon 2 of POLGA and thus RNApII function.
