Sentence examples for by altering the binding from inspiring English sources

What's more, the model also shows that by altering the binding strength of the therapeutic protein component, drug side effects could be further reduced.

This suggests that CIE-induced DNA demethylation may influence NR2B expression by altering the binding of these transcription factors.

All these evidences strongly imply that rs10954213 regulates SLE by altering the binding of IRF5 mRNA and miR-181a.

However, recent findings suggests that the LPL rs320 may be functional by altering the binding of a transcription factor and impacting LPL expression [ 49].

Whether or not a parent methylates a particular gene in the germ line may affect its expression in the offspring by altering the binding of enhancers or repressors.

One class of regulatory mutations, cis-regulatory mutations, are found in close proximity to the genes they regulate and function by altering the binding of transcription factors necessary for gene expression.

As the C-terminal tail of SSB interacts with more than a dozen proteins involved in DNA replication, recombination, and repair (Shereda et al., 2008), our observation supports and expands upon the idea that these proteins might modulate the macroscopic condensation state of the SSB-ssDNA fiber by microscopically altering the binding mode, and therefore either grant or restrict access to the ssDNA.

The polymer conjugation strategy was designed to improve efficacy and safety by optimizing localization to the tumor, by enhancing the PK profile through reduced Cmax and increased exposure, and by altering the receptor binding profile to enhance tumor killing, without any changes to the amino-acid sequence.

Traditional approaches for increasing the affinity of a protein for its ligand focus on constructing improved surface complementarity in the complex by altering the protein binding site to better fit the ligand.

For example, several independent studies found that the actionable mutations in the EGFR gene could activate EGFR by altering the ATP binding site, which ultimately leads to an enhancement of drug response to gefitinib [ 24, 25].

For example, several independent research groups found that the presence of mutations in the EGFR gene (point mutations in exon 21 or deletions in exon 19) could activate the gene by altering the ATP binding site, ultimately leading to an enhancement of the gefitinib response [ 24, 25].