Sentence examples for by altering the accessibility from inspiring English sources

By altering the accessibility of DNA sequences, the nucleosome has profound effects on all DNA-dependent processes.

The positioning and remodelling of the nucleosomes are able to regulate the gene expression by altering the accessibility of regulatory DNA sequences to transcription factors and to the transcriptional machinery [ 36].

DNA methylation, an epigenetic modification, is known as a regulator of gene expression in cell proliferation, differentiation, and reprogramming., In general, CpG methylation was thought to silence mRNA transcription by altering the accessibility of DNA to transcriptional regulators.

Polarization of stimulated T cells with activated NFAT1 is maintained by altering the accessibility of NFAT1 to the chromatin of infg or il4 promoter in TH1 and TH2 cells, respectively [ 7].

By altering the accessibility of chromatin, it also regulates many cellular processes, including development, differentiation and proliferation (Nagl et al, 2005; Gao et al, 2008; Reisman et al, 2009).

Studies suggest that chemically modified histones, such as methylated or acetylated, contribute to gene regulation by altering the DNA accessibility of transcription factors.

By altering the DNA accessibility via eviction and deposition of histones onto the DNA, histone chaperones represent an important regulatory hub in the gene expression webs and hence can potentially exert considerable influence on developmental and physiological processes in plants.

This finding confirmed the direct role of DNA methylation in altering the accessibility of transcription factors to the NR2B promoter.

The simplest hypothesis was that pre-treatment with an HDAC inhibitor increased the accessibility of DNA-damaging agents to their target by altering the chromatin structure, thus enhancing the cytotoxic effects.

The accessibility of large territories of the genome can be regulated by altering the degree of chromatin compaction.

Assuming limited accessibility to cellulose to be the main obstacle for enzymatic hydrolysis [ 30], the effect could tentatively be attributed to improved enzyme accessibility caused by the more severe pretreatment producing a larger surface area by altering the physical shape of the pretreated material, i.e. by creating a more favorable topology.