Sentence examples for by altering its affinity from inspiring English sources
One possibility is that differential phosphorylation events can modulate the role it plays in a cell by altering its affinity for DNA or binding partners, such as c-Jun.
Ultimately, NHE-1 regulators alter transport activity by altering its affinity for intracellular H+ such that it is more active at a more alkaline pHi [ 69].
It is thus tempting to speculate that the photoperiodic modulation of GPR50 regulates the function of the MT1 receptor by altering its affinity for melatonin, and hence modulates physiological responses elicited by this receptor.
We propose that by phosphorylating the Smad2 linker region, p38 increases Smad2 activation by altering its affinity either to the TGF-β receptors or to negative regulators of this pathway, such as Smad7, resulting in higher levels of p-Smad2 and therefore higher levels of Nodal/activin signaling.
The dopants act as attractors of OH groups, making the material prone to oxidation, and therefore altering its affinity towards Na.
We speculate that the G1152K substitution altering its affinity for TONSL and the activity of the resulting complex in the recombination-dependent repair of collapsed replication forks [ 56].
Since TRAX might affect the association between PLCβ1 and Gαq by altering its membrane binding affinity, we determined whether TRAX would interfere with PLCβ1's association with membranes.
In the modified conformational state, CaM is likely to alter its affinity to different targets by increasing and decreasing its affinity to certain proteins.
Apart from its effects on microtubule binding, phosphorylation can alter tau subcellular localization to dendritic spines (127) or can alter its affinity for the plasma membrane (128), thereby causing alterations in synaptic function (127, 129).
The prediction that the sequence modification of VCN would alter its affinity for α5β1 compared to the native molecule was confirmed by this assay.
In such an environment, relatively small shifts in pH will alter the charge of histidine and thereby alter its affinity for DNA.
