The steroid monooxygenase and the P450 may participate in detoxification of LPPE compounds by adding or altering functions of metabolites, similar for example to the P450s involved in fungal detoxification of pisatin [ 44].
Alternatively, ATX or cytokines produced by the transgenic epithelial cells could alter functions of the stroma, which in turn contributes to the tumourigenic process.
Cardiac diastolic dysfunction could be caused by various mechanisms [ 11], including altered function of contractile proteins within the cardiomyocyte.
Therefore, naltrexone may affect dependence on cigarette smoking by differentially altering function and expression of α7 and α4β2 nAChRs in the central nervous system.
By altering the functions of the cricket's central nervous system, the worm coerces it into jumping slap bang into the nearest body of water.
As members of the Gαq family are known to regulate mitogenic pathways [ 39], Fhit may exert its tumor suppressive effect by altering the functions of these Gα subunits.
The high number of protein links of these proteins suggests that a possible inactivation of these genes may cause a major deregulation of patwhays by altering the function of a high number of genes.
Inflammation can reduce the anti-atherogenic and anti-oxidant properties of HDL by altering the function of key enzymes important to the metabolism of HDL.
Hence, impairment of the testicular transcriptional network by altering the function of transcription factors through modulation of their mRNAs or their translation could play a putative role.
Does intrauterine biosynthesis of estrogen play an important role in early pregnancy by altering the function of uterine natural killer (uNK) cells?
