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Our data suggests that methionine might exert a chemoprotective effect on B[a]P DNA adduct formation by attenuating intracellular GSH levels, blocking the uptake of B[a]P into cells, or by altering expression of proteins involved in DNA adduct formation.
The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene.
Increasing DAG accumulation in skeletal muscle by altering expression of adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) leads to the disruption of insulin signaling, and contributes to IR in humans (Badin et al. 2012).
We hypothesized that dieldrin modulates breast cancer pathogenesis by altering expression of novel growth factors thought to be involved in cancer progression.
As pfcrt is also a putative drug/metabolite transporter, changes in expression of various transporting molecules was probably not random, suggesting that mutations in PfCRT might disturb parasite transporting activities; and the parasites responded by altering expression of various transporters, particularly those transporting H+ and lipids.
miR160 regulates development by altering expression of auxin-induced genes through ARF families [ 65, 66].
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Psychological stressors may cause affective disorders, such as depression and anxiety, by altering expressions of corticotropin releasing factor (CRF), serotonin (5-HT), and tyrosine hydroxylase (TH) in the brain.
Increased expression of TOX3 protected neuronal cells from cell death by altering expression levels of genes that affect apoptosis [ 30].
These processes are critical for normal ovarian function, so it is of significance that they are regulated by BPA, which alters expression of this nuclear receptor.
DNA methylation is a covalent modification to CpG dinucleotides and an epigenetic mark used by cells to alter expression of genes without permanently changing the DNA sequence.
It has been proposed that the changes in the RA synovium are a random process, caused by, for example, altered expression of p53 [ 8, 9].
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