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Free radicals play vital role in tumor promotion by alteration of cellular metabolic processes and their scavengers (SOD and LPx).
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In contrast to low oxygen conditions, the hypoxia-mimic response induced by Ni may be accompanied by alterations of cellular iron levels.
The alteration of cellular functions by anchoring macromolecules to specified organelles may reveal a new area of therapeutic potential and clinical treatment.
The transcription factor, CEBPα is implicated in the regulation of numerous liver-specific genes and it is a critical regulator of hepatic metabolism [42] [46] and our results are in agreement with earlier reports [47], [48] that show a significant inhibition of CEBPα by TNFα thereby implying a major alteration of cellular metabolism.
Alteration of cellular functions by binding to certain thiol groups of biomolecules is the most commonly invoked pathway for Cd toxicity (Joseph 2009).
Since S-glutathionylation is the linkage of two cellular thiol pools, we also show the amount of protein S-glutathionylation in response to the alteration of cellular thiol pools by two different means.
They include the presence of viral nucleic acids, viral proteins, or alteration of cellular factors induced by viral oncoproteins (Table 1).
The consequent alteration of cellular redox state is potentiated by the correlated decrease of antioxidant and energetic reserves.
Berglund, P., Finzi, D., Bennink, J.R. & Yewdell, J.W. Viral alteration of cellular translational machinery increases defective ribosomal products.
The Ca(2+)/CaM complex initiates a plethora of signaling cascades that culminate in alteration of cellular functions.
A study published by the Federation of American Societies for Experimental Biology found that even a modest disturbance of sleep produced a reduction of natural immune responses and an alteration of cellular immune functions.
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