Further studies are required to understand the molecular mechanisms driven by alterations in A-type lamins on Rb signaling pathways.
Detecting particular proteins in a clinical setting, says Barsky, is relatively routine; if the structural changes are caused by alterations in a protein, detecting that protein would be cheaper and easier than using atomic-force microscopy.
Looking through a standard list of Mendelian diseases, which are those caused by alterations in a single gene, the Sanger team found that mutations in 169 of the synaptic genes led to 269 different human diseases.
The increase in hepatic succinate caused by exposure to PB could have been caused by alterations in a number of different pathways, including increased TCA rate and increased reducing potential demand by the liver cells.
Cluster_03-02 represents, in larepresentssinnalargepartwaysignalinge activated by alterations in a cell's immediate surroundings and are transmitted via actin cytoskeleton–anchored FAs, such as NC_SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE; TAGS = 68% [ 31].
Tumours with elevated ZNF703 levels were characterized by alterations in a lipid metabolism and detoxification pathway in which DHRS2 (Hep27), a short-chain dehydrogenase family member, acts as a key nuclear signalling component (Fig 3A; Fig S3A).
Loss of ErbB4 or p35 in mice gives rise to a similar phenotype characterized by alteration in tangential migration and a reduction in the number of interneurons in the adult Cx (this study; Flames et al. 2004; Rakić et al. 2009).
Possibilities include alteration of interactions with other proteins, as has been suggested for the exon 6 indel [ 22, 23], or changes in the isoforms by alterations in splicing, a mechanism demonstrated for rs2004640 [ 2], but with little relevance [ 22].
For example, the onset of cardiac hypertrophy is influenced by alterations in muscle-specific A-kinase Anchoring Protein (mAKAP) signaling in myocytes.
Potentially, our results in these mouse models could be accounted for by alterations in sensory responsiveness, a common feature of autism.
