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In this study, the porcine 4n embryos were complemented by aggregation with normal 2n embryos.
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PTE may prevent protein aggregation and enable cells to function normally with normal levels of FET family proteins.
The hydrogels were formed by micelle aggregation with rising temperature.
Defects of ATP release in uremic platelet dysfunction parallel observations in inherited platelet function disorders, even with normal aggregation results [ 31].
It was probably caused by aggregation of particles with high concentration of positive charge ion.
Amyloid diseases are characterized by misfolding and aggregation of normal soluble peptide into β-sheet-rich oligomeric structures and amyloid fibrils in specific tissues [1].
IT has long been known that the stability of proteins with respect to denaturation (as defined by aggregation) is lowered upon treatment with ionizing radiation1.
Prion diseases are fatal neurodegenerative disorders characterized by misfolding and aggregation of the normal prion protein PrPC.
We previously noted remarkable proinsulin aggregation in normal islets in Akita mice with significantly increased proinsulin aggregates resulting from an Ins2+/Akita mutation.
This suggests that natural genetic variants that are shaped by selection can both provide protection against protein aggregation and toxicity, and, at the same time, be compatible with normal development and physiology.
The results obtained with normal PABPN1 sequence show that higher scores for aggregation propensity are located within the RRM domain (Fig. 4B).
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