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GADD45 was identified as a gene upregulated by agents that cause DNA damage (Fornace et al., 1988).
H2O2 was indeed selective for MSH2 deficiency (2-fold difference at 1 nM H2O2, Fig 1M), supporting the suggestion that MSH2 selectivity could be achieved by agents that cause oxidative damage.
Thus, DNA replication stress in CHK1-depleted HCT116 or p53−/− tumour cells triggers premature histone H3 phosphorylation in response to DNA replication stress, and this is not affected by agents that cause mitotic arrest.
Some of these agents (e.g., histamine, serotonin, VEGF-A) are normally stored in tissue mast cells [ 37– 39] and so may be released by agents that cause mast cell degranulation, e.g., allergy, insect bites, etc. Single exposure to any of these permeability factors results in a rapid but self-limited (complete by 20 30 min) influx of plasma into the tissues.
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This suggests a mechanism by which environmental agents that cause oxidative stress may alter the course of cellular responses through induction or enhancement of signaling cascades leading to functional changes or cell death.
The genome is continuously attacked by a variety of agents that cause DNA damage.
The conventional periodontal therapy mainly includes "SRP," which involves mechanically cleaning the teeth above and below the gum line by removing the etiologic agents that cause inflammation.
It could aggravate the symptoms by amplifying the very inflammatory agents that cause them.
As cells divide, their genome is under constant threat by intrinsic damage and exogenous agents that cause DNA lesions.
Finally, some might argue that our case definition of MSD could bias our pathogen-specific disease estimates by overestimating the importance of agents that cause dysentery.
The integrity of DNA is continuously challenged by metabolism-derived and environmental genotoxic agents that cause a variety of DNA lesions, including base alterations and breaks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com