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David Bartel studies molecular pathways that regulate eukaryotic gene expression by affecting the stability or translation of mRNAs.
On the one hand, it is clear from the converged FES of the monomer that it destabilises the aTKD dimer interface by affecting the stability of the αC helix.
Second, viruses inhibit the MHC class II antigen presentation pathway by affecting the stability or intracellular sorting of class II proteins.
Structural analysis suggests that these two novel mutants may account for the milder phenotype by affecting the stability of EDA trimers.
miRNAs function as post-transcriptional regulators, mainly by affecting the stability of their target mRNAs (Guo et al., 2010).
IAPs can regulate the plasticity of tumor cell migration by affecting the stability and activation of Rho GTPases.
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Skottke et al. (2011) showed that PP2A mediates a finely tuned regulation of overall ethylene production by differentially affecting the stability of specific classes of ACS enzymes.
In 3937, the T3SS genes are also regulated by an alternative pathway in which the RsmA protein down-regulates T3SS genes by affecting the mRNA stability and translation of hrpL.
The observed decrease in intraparticle pH during conversion of cephalosporin C by the Sepabeads EC-EP immobilizate of the amidase suggests that removal of diffusional limitations through optimized carrier geometry should enhance reaction performance, by not only increasing the rate during the initial phase of the conversion, but also by affecting the operational stability of the enzyme.
Interferon (IFN -γ, the cytokIFN -γatheharacytokine thatTh1 pattern, strongly inhibits the proliferation of SMcharacterizesoducthen of inTh1stitial collagens by vascular SMCs, affecting the stability of the fibrous capattern
In addition, the presence of a protein cannot be implied to indicate its functionality as pathogenicity can be caused by functional problems not affecting the stability of the protein [Mangold et al., 2005; Raevaara et al., 2005].
More suggestions(15)
by affecting the steady
by affecting the flow
by affecting the expression
by affecting the composition
by affecting the suspension
by affecting the way
by affecting the membrane
by affecting the host
by affecting the concentration
by affecting the sorting
by affecting the blood
by increasing the stability
by affecting the number
by affecting the mu
by affecting the brain
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Justyna Jupowicz-Kozak
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