Sentence examples for by affecting the localization from inspiring English sources
Computer-assisted SAR analysis of compound B revealed that its furan-associated bicyclic nucleus harbors the antitubulin activity of the compound whereas its C2 side chain is important for overall activity, possibly by affecting the localization of the compound to the tubulin pocket.
The effects of Akt1 on GluRIIA localization could therefore be mediated by either regulated delivery of GluRIIA-containing vesicles to the plasma membrane, or by affecting the localization to the postsynaptic density following insertion into the plasma membrane.
Depletion of DNMT1 prevents accumulation of H3S10P foci, perhaps by affecting the subnuclear localization or the binding affinity of Aurora kinases to the centromere (Monier et al. 2007).
While TOR signaling usually exhibits its regulatory function by affecting the cellular localization of transcription regulatory proteins, we also see significant transcriptional control of TOR responsive TFs in P. pastoris.
For example, in the experiment shown in Fig. 8 c, the training distance is about 3400 m and SmartLoc estimates the following 1200 m (with GPS off), which reduces the energy by approximately 10%% without affecting the localization accuracy.
Although not fully elucidated, it is widely thought that the risk variants of these lipoproteins promote AD pathogenesis by affecting the extracellular concentration, localization and/or fibrillization of Aβ.
To test whether DRAM-3 loss has an effect on autophagy by affecting the number or localization of structures associated with autophagy – phagophores, autophagosomes and autolysosomes/lysosomes – we stained wild type (Crispr GFP) and DRAM-3 Crispr cells with antibodies against WIPI2, LC3B and LAMP2.
To determine whether the activation of SRC by RASSF1C affects the localization, we tracked GFP-SRC and pY416-SRC by florescence microscopy.
Therefore, it is likely that the CTG-induced effect on TBPH occurs at a more downstream level, for example by affecting the transport of TBPH mRNAs and/or TBPH protein, or by triggering post-translational modifications that affect protein localization.
In this study, it was found that inactivation of PI3K (III) in the wing primordial cells by knockdown of dVps15 affects the localization of these membrane proteins differently.
(6) The concrete value of the distance bias caused by the inaccurate clock does not affect the localization performance of the LS or WLS estimators. .
