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A blood pressure that is dangerously low may be raised to safer levels by affecting the activity of the offending drug in one of many different ways.
That distinguishes it from microRNAs, which control many proteins simultaneously.A hypothetical RNAi drug might, for instance, become the ultimate analgesic by affecting the activity of SCN9A, a gene recently pinpointed as the reason why a Pakistani street performer who put knives through his arms and walked on burning coals could not feel pain.
These data suggest that the inhibition of lamin A/C phosphorylation by Parp inhibitor was not caused by affecting the activity of cdc2 kinase.
Thus manoeuvres that affect PrP1 might change the phosphorylation and activity of fNKCC1 directly as well as indirectly by affecting the activity of SPAK/OSR1, whilst they would not be expected to affect fNKCC2A.
RT-PCR analyses showed no differential expression of FT, whereas there was some repression of SOC1 in sr45-1 compared to WT (Figure 5C and D), suggesting that the elevated level of FLC in sr45-1 is causing late-flowering phenotype by affecting the activity of some other downstream components.
Furthermore, recent findings suggested that MMPs can modulate inflammation and innate immunity by affecting the activity of various nonmatrix proteins (Parks et al. 2004).
Similar(43)
Furthermore, O2∙− increases ADMA by affecting the activities of protein arginine N-methyltransferases that synthesize ADMA and dimethylaminohydrolase which metabolises ADMA.
22 PRL-3 is also reported as a regulator of H3K9 methylation by affecting the activities of JMJD1B and JMJD2B in colorectal tumorigenesis.
Fluroxene metabolism and toxicity are modified by drugs metabolized by or affecting the activity of the microsomal cytochrome P-450-system or enzymes involved in ethanol metabolism.
By selectively affecting the activity of different neurons, VTA astrocytes may be positioned to coordinate avoidance and approach behaviors.
It is possible that Nestin regulates the Wnt/β-catenin pathway by indirectly affecting the activity of GSK-3β in breast CSC.
More suggestions(17)
by affecting the operational
by affecting the self-organization
by affecting the way
by reducing the activity
by affecting the membrane
by affecting the concentration
by affecting the number
by affecting the mu
by affecting the protein
by dividing the activity
by affecting the recombination
by affecting the supply
by affecting the phosphorylation
by increasing the activity
by regulating the activity
by observing the activity
by affecting the release
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Justyna Jupowicz-Kozak
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