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Thus, the therapeutic effect of MSCs pretreated with IFN γ, TNF α, and IL-17 on ConA-induced liver injury was mainly dependent on their robust suppression of T-cell proliferation, but not by affecting differentiation of T-cell subpopulations.
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All cooperative interactions affected differentiation of photoreceptor development as judged by ELAV staining (Fig. 4C).
Suzuki, H. et al. Glycolytic pathway affects differentiation of human monocytes to regulatory macrophages.
Hence, cardiac milieu appears to stimulate proliferation but does not affect differentiation of skeletal myoblasts.
This agent is known to negatively affect bone metabolism by means of increasing bone resorption and to inhibit bone formation by affecting the differentiation of early osteoblastic cells [ 25].
Several studies have suggested that Wnts might contribute to skin fibrosis in systemic sclerosis (SSc) by affecting the differentiation of pluripotent dermal cells.
In order to demonstrate that knockdown of SMS1 and SMS2 by siRNA did not affect differentiation, expression of the neutrophil cell-surface marker CD11b was determined.
Dimethyl sulfoxide (DMSO) alters the epigenetic DNA methylation profile of mouse embryoid bodies causing phenotypic changes in embryonic stem cells by stimulation of Dnmt3a and affect differentiation in several cell-lines.
In normal breast development, progesterone directs the formation of lobular-alveolar structures and also affects differentiation in the breast by modulation of milk protein synthesis [ 1].
In addition, constraints on aggregate size imposed by the action of fluid forces in the bioreactor affect differentiation.
By contrast to its promoting effects on osteogenesis in endochondral ossification, targeted overexpression of FGF9 in cranial mesenchymal cells leads to a switch from intramembranous to endochondral ossification in mouse parietal bones, indicating that FGF9 may regulate bone development by affecting the direction of mesenchyme differentiation.
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