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Hence, the dependence of N5 activity on tether length suggests that even though N5 does not act as a Gβγ mimic, its ability to stimulate channel activity by affecting cell surface expression requires some degree of proximity to the channel.
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Expression of this domain, however, significantly affects cell surface architecture by the formation of abnormally long and fragile filopodia that poorly attach and retract abnormally.
In addition, Aqy1p and Aqy2p can affect cell surface properties and may provide an advantage by dispersing the cells during starvation or during sexual reproduction.
It is possible that the altered cell morphology caused by the presence of PaxDN constructs could be attributable to perturbed expression of cell surface antigens, since Pax3 is known to affect cell surface properties [37], which may affect cell shape by changed adherence to the tissue culture substrate.
Our study demonstrated that AuNPs significantly inhibited VEGF165-induced HUVEC migration and tube formation by affecting the cell surface ultrastructure, cytoskeleton and might have inhibited angiogenesis via the Akt pathway.
In contrast to the previously reported inhibitory effect of HS on LfcinB, the present study shows that the cytotoxic activity of small lytic peptides was increased or not affected by cell surface HS.
The extracellular symbiont in the gut cavity is less likely to be affected by host innate immunity, which might affect its cell surface molecules.
Previous study has shown that the CCN family affects cell functions by binding to cell surface integrin receptors [ 32].
As shown in Figure 6a, DHA treatment alone did not affect the cell surface expression levels of IFNγR1 or IFNγR2 as assessed by mean fluorescent intensity.
Neither drug alone significantly affected the cell surface area.
By analogy, we speculate that aberrant expression of the SPI2 TTSS apparatus compromises the ability of Salmonella to form biofilm, perhaps by affecting the presentation of cell surface factors such as curli.
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