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Increasing evidence also indicates that cancer-specific changes in annexin expression or in their subcellular localisation contributes to development and progression of cancer by affecting cell signalling pathways, cell motility, tumour invasion and metastasis, angiogenesis, apoptosis, and drug resistance (Hayes et al, 2007; Mussunoor and Murray, 2008).
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Nonetheless, engagement of yet known viral receptors on rodent cells by HIV or soluble gp120 can affect cell signaling pathways and often cell death in neural cells [29], [60].
On the other side of the SOD reaction, free radicals can also affect cell signalling by attenuating NO (nitric oxide) signalling and are necessary for long-term potentiation [ 2, 12].
Hormonal modulation affects cells signaling.
The results of this clinical trial demonstrated that daily intake of 25 g flaxseed can significantly reduce cell proliferation, increase apoptosis, and affect cell signaling by reducing HER2 expression of breast tumors.
MF may inhibit A549 cells and can increase their sensitivity to RT, possibly by affecting cell cycle- and apoptosis-related signaling pathways.
TanIIA inhibits the growth of esophageal cancer cells and induces apoptosis in a time-dependent and concentration-dependent manner, possibly by affecting cell cycle- and apoptosis-related signaling pathways.
These data indicate that the mechanism of these four Chinese herbs treating RA and CHD is partly through affecting cell apoptosis by regulating apoptosis-related signal pathway, which are consistent with some experimental results [ 28, 29].
Tyrosine phosphorylation of tubulin in microtubule polymer might affect the cell signaling by enhancing the Src-homology 2 (SH2) domain-mediated interaction between microtubules and signaling molecules.
A future challenge will be to systemically identify all of the miRNAs affecting, and regulated by, the dysregulated cell signalling pathways in ADPKD.
Therefore, the aforementioned heterogeneity may be caused by the random fluctuations that unavoidably affect cell regulation and signalling.
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