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This was accomplished by adjusting the analyses for self-rated health, which is a strong determinant of disability retirement [ 32].
We have attempted to address this issue by adjusting the analyses for tumour stage at the time of recruitment assuming that patients who are diagnosed with more advanced disease would present with greater amount of weight loss.
13 14 The effect of occupation on the relation between job strain and mortality has in most studies been accounted for by adjusting the analyses for at least one of the common socioeconomic indicators, occupational class, education and income.
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We have tried to control for this as much as possible by adjusting the multivariate analyses by demographic factors, traditional cardiovascular risk factors, comorbidity, and drug use.
In the current study, we first conducted the sensitivity analyses by adjusting the social discount rate and evaluation period.
Genes with high variability within samples were selected by pair-wise comparison analyses performed by adjusting the type-I error for multiple tests (Step-down permutation (SDP) [ 10], and False Discovery Rate (FDR) [ 11]), and with no type-I error adjustment (Raw method).
To determine whether the association of total testosterone with metabolic syndrome was influenced by SHBG, we adjusted the analyses for SHBG.
Furthermore, because it is well established that vitamin E levels are affected by circulating lipids, we further adjusted the analyses for total cholesterol.
However, we adjusted the analyses for seasonality by incorporating the timing of the sampling, which should partly address this issue.
For each predictor, we also performed multivariable-adjusted analyses by adjusting analyses for the type of arthroplasty (TSA versus HHR) based on our clinical prediction that arthroplasty type might be associated with mortality.
Smoking is a well-known cardiovascular risk factor and by adjusting our analyses with cardiovascular diseases and cardiovascular medications we have tried to minimise the confounding effects of smoking on our results.
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