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A mathematical model suggests this might be due in part to the sequestration of the TF by additional copies of its cognate promoter.
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Schiffman says that he and his colleagues are trying to determine whether they can make human cells more elephantlike, for example by inserting additional copies of the p53 gene or by identifying compounds that duplicate the effects of the extra copies.
It is possible that increasing the levels of oligomeric aggregates, by introducing additional copies of the wild-type Aβ42 transgene, or by ageing the flies for longer, might also elicit circadian abnormalities.
The B. subtilis high-performance riboflavin production strain BSHP was constructed by introducing additional copies of the B. subtilis ribGBAHT genes controlled by strong constitutive phage promoters (P spo) into the genome of B. subtilis strain 3979 [ 18, 32].
The user can transfer that copy to up to five other Windows computers, but only by buying additional copies of the software for $20 each.
A highly efficient construct was created by assembling additional copies of DFRsyn and LARsyn enabling a titer of 374.6±43.6 mg/L of -catechin.
Off-path caching and replication are facilitated by registering additional copies of an information object stored at Internal Nodes to the NRS.
By extension, additional copies of SLC2A3 may confer protection to patients, and lead to HD manifesting later in life.
By introducing additional copies of the afsR or afsS genes into S. coelicolor, actinorhodin production could also be increased [ 145].
To create the final version of the vector, we improved the amiRNA/HSV-TK expression cassette by incorporating additional copies of pTP-mi5 hairpins into the EGFP/amiRNA transcription unit.
The expression response curve for the gene could be vertically shifted upward by introducing additional copies of the gene under the control of a constitutive (unregulated) promoter, as this would contribute a flat baseline expression rate.
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