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Although the human homolog of this domain has no RNA binding capability, this function may be fulfilled by additional components of human eIF3 which are missing in yeast.
Thus, while our data directly implicates the retrograde signaling transcription factor Rtg1/3 in the regulation of extracellular ATP, regulation of this phenotype by additional components of the RTG pathway remains to be more fully characterized.
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The specificity upstream of the core module may be regulated by additional components like scaffold proteins that help bring the specific components of the MAPK machinery together or keep various components from interacting with each other.
This basic design can be supplemented by additional components in some TPS systems.
In addition to Spc42, the satellite is predicted by immunoEM to contain three additional components of the core SPB: Spc29, Nud1, and Cnm67 (Adams and Kilmartin, 1999).
In this study we build on the prior studies modeling APC inactivation of FVa [ 33] by incorporating the presence of additional components of the prothrombinase complex (FXa and prothrombin) to construct an empirically validated mathematical model.
To validate features revealed by transcriptome analysis and to identify additional components of oxidative stress-mediated apoptosis, we further conducted a series of cellular and molecular assays.
The formation of β-carotene crystals in these cells seems to be solely driven by the overexpression of AtPSY, not requiring additional components of a chloroplast or chromoplast developmental program that does not exist in Arabidopsis.
In addition, the proliferation and differentiation of wing cells is very sensitive to changes in the level of signalling, allowing the identification of additional components of these pathways by both loss- and gain-of-function genetic screens.
- Furthermore, ULK1 interacts with the synaptic proteins SYNGAP1 and SDCBP/syntenin-1, and the latter is directly phosphorylated by ULK1., However, the role of the additional components of the ULK1 complex in general and of ATG13 in particular for this neuron-specific function remains rather elusive.
We have investigated additional components of the whirlin interactome by identifying interacting partners to p55.
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