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However, it is now clear that CCR3 is expressed by additional cell types.
This data clearly supports the antibody analyses in Fig. 1; thus, we suspect the differences seen between the individual gene comparisons and the antibody-derived data might reflect Nos2 and Arg1 gene expression by additional cell types in the wound.
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Group 4 species resolve this problem by additional cell-type specialization to form support structures.
This choice enables us to expose the dynamical consequences of the structure of the local microcircuit in spiking cortical networks unaffected by additional cell-type specificity (e.g. Brémaud et al. 2007; Lefort et al. 2009).
This could be accomplished by including additional cell types in the model.
Tamoxifen may persist in the liver for 1-4 weeks after injection, and higher doses can cause nonspecific recombination. 3 Either may confound accurate fate mapping by labeling additional cell types.
Nevertheless, adhesion of epithelial TCs to the microvascular endothelium may also be mediated by indirect cell adhesion, using additional cell types or soluble molecules within the blood [ 31, 32].
This interesting finding led us to the hypothesis that in the presence of additional cell types not eliminated by a Percoll purification step (e.g., Kupffer cells or damaged hepatocytes), gene expression changes occur already at concentrations that do not show an effect on the viability of the cells.
Because LIR-1 is only expressed by a subset of NK cells, it is unclear whether NK cells are the main target population or whether additional cell types are also influenced by UL18.
Similar results were observed in two additional cell types that were transiently transfected and analyzed by FRAP (Fig. S2).
Moreover, Geron will no longer have the option to acquire exclusive rights to additional cell types.
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