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To claim you invented a whole mouse merely by adding three genes is absurd, but the original oncomouse claim was to patent the entire animal.
In June, a group reported success with the model plant Arabidopsis; by adding three genes, researchers led by Baoxiu Qi of the University of Bath, U.K., created plants in which EPA made up 20% of the plant's oils.
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Instead, they could turn an already developed cell, like a skin cell, into a stem cell by adding four genes.
Kang et al. designed an artificial Neu5Ac biosynthetic pathway through intermediate N-acetylglucosamine 6-phosphate by adding two genes slr1975 and GNA1 into E. coli.
A team led by Marius Wernig, a postdoc in the lab of stem cell researcher Rudolf Jaenisch at the Massachusetts Institute of Technology in Cambridge generated iPS cells from mouse tail cells by adding four genes.
At the time, he and others were trying to reprogram cells by adding one gene at a time.
The BN+1 method expands a top Bayesian network by adding one gene at a time and running it iteratively based on microarray gene expression data.
We added three genes coding for antibacterial peptides to this list, which were previously shown to be controlled by PlcR: sppc1, sppc2 and sppc3 [22].
We indicate the fact that AD x) and AD y) belong to the same AD-component in R by adding two dummy genes b1 in AD x) and b2 in AD y), and a bridge { b 1, b 2 } in E (B ).
But in 2007 two groups of researchers, one in Japan and the other in America, announced that they had worked out how to make adult skin cells behave like natural pluripotent cells, by adding four activated genes to them.
Specifically, starting from the top ranked gene, one gene was added at each step to the gene set, until the classification accuracy could not be improved by adding one more gene.
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