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The second procedure was to check the possibility of a linear trend over the period 1971-2007 by adding interaction effects between marital status and period (operationalized as year minus 1990, so the main effects of marital status could be interpreted as the effects in 1990, which is in the middle of the study period).
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We estimated season-specific effects by adding interaction terms between pollutant concentration and seasons to our mortality risk model.
For each outcome, interactions between treatment effects were tested by adding interaction terms to the relevant Cox models and comparing the likelihood statistics for the models with and without interaction; this will thus be termed a test for an additive interaction here.
After variables of interest were identified, we assessed for confounding by age, sex, and socioeconomic status by wealth index 9 as well as the presence of effect modification by adding interaction terms.
Finally, we tested for modification effects by sex, by adding interaction terms to the models.
The interaction effect of FGF23 and other variables on the outcome was estimated by adding interaction terms between FGF23 categories assigned serial numerical codes and the status of other variables (below and above the median) to the relevant model.
We examined interactions with statins for metals associated with BP in any regression by adding interaction terms between metals and statin use (yes/no) to main effects models and by modeling stratified regressions.
Fourth, we tested the possible moderating effect of personality on career success by adding interaction terms to the model.
We formally tested for interactions between the effect of atorvastatin and CRP or LDL-cholesterol by adding interaction terms (atorvastatin × CRP above/below targets) to the Cox models.
Protective effects of co-exposure to DHA or selenium were also tested by adding interaction terms to model 3.
The effect of mechanical ventilation during the first 24 hours was examined by adding interaction terms to the multiple logistic regression model for each factor individually.
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