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The internal standard (IS) was used as a hydrochlorothiazide (HCT) in HPLC measurements.

The objective of this study is to compare the effects of 2 types of diuretics, indapamide and hydrochlorothiazide, added to an angiotensin-converting enzyme inhibitor, on ventricular and arterial functions in patients with hypertension and diabetes.

OBJECTIVE: The objective of this study is to compare the effects of 2 types of diuretics, indapamide and hydrochlorothiazide, added to an angiotensin-converting enzyme inhibitor, on ventricular and arterial functions in patients with hypertension and diabetes.

The most common antihypertensive medications added to a patient's regimen were ramipril (10 patients), hydrochlorothiazide (9 patients), and irbesartan (8 patients).

At 12 weeks, hydrochlorothiazide 12.5 to 25 mg could be added, followed by amlodipine 5 to 10 mg daily.