We construct a null model of a transcriptional regulatory network (TRN) by adapting the "sequence-matching" rule which we have introduced earlier [16], [17] as a condition for the establishment of edges between nodes of a network.
This could be negated by adapting the 4Cv technique to sequence the amplified material using a high-throughput sequencing approach or further optimization of the digestion conditions.
In addition to compare natural RNAs against structural analogs, we could generate random sequences by adapting the nucleotide composition of the pool [ 47, 48].
The run time of Inparanoid is reduced by a few orders of magnitudes by adapting the software to use BLAT (Kent, 2002) for sequence alignments.
To generate the CD36 ECFP fusion we adapted the sequence swapping protocol proposed by the Quikchange XL mutagenesis kit [38].
We have now adapted the sequence of the ECLs presented by CX4-M1 thethe recently published crystal structure of CXCR4.
It is achieved by dynamically adapting the quantization parameters depending on the desired target quality without any a priori knowledge about the sequence characteristics.
We show here that their results can be improved by adapting these time intervals to the sequence of maps.
The Rotterdam classification system of variants was adapted from the sequence variation classification proposed by Plon et al. (2008).
Studies in which indels are particularly important, such as on human diseases [ 24, 25], might need to adapt the approach by deeper sequencing and allowing SAMtools to call indels (see online supplementary bioinformatics protocol) or by avoiding using 454 altogether.
We conducted and evaluated fit sequences by slightly disturbing all model parameters before again adapting the model to time series data.
