These results suggest that late spikes with poor temporal precision are generated by the activation of postsynaptic KARs selectively present in DGCs from epileptic rats.
Important aspects of the dopaminergic pathway include synthesis of dopamine in dopaminergic neurons, release of dopamine by presynaptic neurons, receptor activation of postsynaptic neurons, dopamine re-uptake by presynaptic neurons, and metabolism of released dopamine.
The fractional contribution of NMDA-type glutamate receptors (NMDARs) were significantly different for CIN-evoked glutamatergic responses compared to those arising from optical stimulation of corticostriatal projections, suggesting differential activation of postsynaptic receptors by these two afferent populations.
The activation of postsynaptic NMDA receptors by glutamate released in an idealized, 3D neuropil has been described elsewhere [31], [32], [33].
When mediated by synaptic interactions, the repetitive firing of presynaptic neurons can cause oscillatory activation of postsynaptic neurons.
In line of the recurrent network described in the LA [27], activation of postsynaptic NPS receptors on LA projection neurons followed by depolarization and action potential generation (see above) could give rise to the observed increase in sEPSCs.
The endocannabinoid -LTD was presynaptically expressed and depended on the activation of postsynaptic mGluR5, phospholipase C and a rise in postsynaptic Ca2+ as predicted from the localization of the different components of the endocannabinoid system.
These and other hippocalcin-dependent signalling processes involve activation of postsynaptic glutamate receptors.
Collectively, these results demonstrate that Irs2 null mice display inadequate activation of postsynaptic NMDARs.
The induction of withdrawal LTP at C-fibre synapses in vitro [ 18 ] requires activation of postsynaptic G-proteins, postsynaptic NMDA-receptors and a rise in postsynaptic Ca2+ levels [ 18 ].
